antimicrobial and antibiofilm activity of human cationic antibacterial peptide (ll-37) and its analogs against pan-drug-resistant acinetobacter baumannii

نویسندگان

yijie guo department of pathogenic microbiology and immunology, school of basic medical sciences, xi’an jiao tong university, xi’an 710061, china; department of pathogenic microbiology and immunology, school of basic medical sciences, xi’an jiao tong university, xi’an 710061, china. tel: +86-2985267814, fax: +86-2985267814

ling wang department of biological science and engineering, shaanxi university of technology, hanzhong, 723001, china

jine lei clinical laboratory, the first affiliated hospital of xi’an jiao tong university, xi’an jiao tong university, xi’an 710061, china

jiru xu department of pathogenic microbiology and immunology, school of basic medical sciences, xi’an jiao tong university, xi’an 710061, china

چکیده

results ll-37 and its truncated analogs were effective in inhibiting the growth of pdrab and had a rapid killing ability. after exposure to the peptides, the development of the pdrab biofilm was inhibited. strong inhibitory and dispersion effects of ff/cap18 on the biofilm were confirmed by fluorescence microscopy and field emission scanning electron microscopy. conclusions this results show that ff/cap18 is a potential antimicrobial agent for treating pan-drug–resistant bacterial infections. objectives this study aims to clarify the antimicrobial activity of ll-37 and its analogues against pdrab. methods in this study, we evaluated ll-37 and its truncated analogs inhibitory effect on the growth of pdrab by minimum inhibitory concentration (mic) and minimum bactericidal concentration (mbc) analysis, we also examined the effect of ll-37 and its analogs on bacterial biofilm formation by using a quantitative crystal violet assay. background human cationic antibacterial peptide hcap18/ll-37 is the only known cathelicidin, which is part of the innate immune system of humans. the antimicrobial activity of ll-37 against multi-drug-resistant acinetobacter baumannii has been reported recently, however, whether ll-37 and its analogues (ll/cap18 and ff/cap18) have antimicrobial activity against pan-drug-resistant acinetobacter baumannii (pdrab) is still unknown.

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عنوان ژورنال:
jundishapur journal of microbiology

جلد ۱۰، شماره ۳، صفحات ۰-۰

کلمات کلیدی
[ ' d r u g r e s i s t a n t ' , ' a n t i b a c t e r i a l p e p t i d e l l ' , 3 7 , ' a c i n e t o b a c t e r b a u m a n n i i ' ]

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